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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F5
All Species:
10.91
Human Site:
S278
Identified Species:
17.14
UniProt:
Q15329
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15329
NP_001077057.1
346
37610
S278
N
L
P
E
Q
H
V
S
E
R
S
Q
A
L
Q
Chimpanzee
Pan troglodytes
XP_511025
426
45548
S263
Q
E
A
S
R
P
N
S
P
Q
L
T
P
T
A
Rhesus Macaque
Macaca mulatta
XP_001094919
346
37697
S278
N
L
P
E
Q
H
V
S
E
R
S
Q
T
L
Q
Dog
Lupus familis
XP_853833
304
33793
Q240
E
H
V
S
E
R
S
Q
N
L
Q
Q
T
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61502
335
36766
S268
N
L
P
E
Q
H
V
S
E
R
S
Q
T
F
Q
Rat
Rattus norvegicus
Q62814
300
33206
F239
V
S
E
R
S
Q
N
F
Q
Q
T
P
A
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517985
227
25092
R165
E
H
N
L
S
R
E
R
L
R
Q
T
P
V
S
Chicken
Gallus gallus
Q90977
403
43534
E337
L
P
T
K
C
P
T
E
D
V
S
L
S
P
L
Frog
Xenopus laevis
NP_001086706
375
40890
T240
I
A
T
S
P
A
P
T
V
P
H
S
T
I
S
Zebra Danio
Brachydanio rerio
NP_998597
393
42365
A240
A
N
S
T
P
S
P
A
S
T
C
Q
S
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
A596
K
R
R
R
E
A
A
A
A
A
I
A
A
G
S
Honey Bee
Apis mellifera
XP_624285
300
34327
K239
D
A
E
L
I
E
A
K
I
V
L
R
D
V
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799123
356
39484
N288
E
V
T
E
E
S
L
N
G
A
S
P
E
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130952
446
48668
L359
E
S
N
I
H
G
G
L
I
L
P
S
D
A
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565831
483
52579
S395
N
P
E
T
A
I
V
S
H
D
H
P
H
P
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.8
97.9
78.9
N.A.
88.1
82.6
N.A.
57.2
33
58.1
56.2
N.A.
20.6
41
N.A.
51.9
Protein Similarity:
100
62.2
98.5
82.6
N.A.
90.1
84.3
N.A.
60.6
49.6
68.8
66.1
N.A.
29.6
55.2
N.A.
65.1
P-Site Identity:
100
6.6
93.3
6.6
N.A.
86.6
6.6
N.A.
6.6
6.6
0
6.6
N.A.
6.6
0
N.A.
13.3
P-Site Similarity:
100
20
93.3
13.3
N.A.
86.6
33.3
N.A.
13.3
26.6
13.3
20
N.A.
20
20
N.A.
40
Percent
Protein Identity:
N.A.
31.3
N.A.
28.1
N.A.
N.A.
Protein Similarity:
N.A.
45
N.A.
41.2
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
0
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
7
0
7
14
14
14
7
14
0
7
20
7
14
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
0
7
7
0
0
14
0
0
% D
% Glu:
27
7
20
27
20
7
7
7
20
0
0
0
7
0
7
% E
% Phe:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% F
% Gly:
0
0
0
0
0
7
7
0
7
0
0
0
0
7
0
% G
% His:
0
14
0
0
7
20
0
0
7
0
14
0
7
0
0
% H
% Ile:
7
0
0
7
7
7
0
0
14
0
7
0
0
7
0
% I
% Lys:
7
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% K
% Leu:
7
20
0
14
0
0
7
7
7
14
14
7
0
14
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
27
7
14
0
0
0
14
7
7
0
0
0
0
0
0
% N
% Pro:
0
14
20
0
14
14
14
0
7
7
7
20
14
27
7
% P
% Gln:
7
0
0
0
20
7
0
7
7
14
14
34
0
0
27
% Q
% Arg:
0
7
7
14
7
14
0
7
0
27
0
7
0
0
0
% R
% Ser:
0
14
7
20
14
14
7
34
7
0
34
14
14
7
34
% S
% Thr:
0
0
20
14
0
0
7
7
0
7
7
14
27
14
0
% T
% Val:
7
7
7
0
0
0
27
0
7
14
0
0
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _